/*
  This work is in the public domain and may be reproduced, published or
  otherwise used without the permission of the National Library of Medicine (NLM).

  We request only that the NLM is cited as the source of the work.

  Although all reasonable efforts have been taken to ensure the accuracy and
  reliability of the software and data, the NLM and the U.S. Government  do
  not and cannot warrant the performance or results that may be obtained  by
  using this software or data. The NLM and the U.S. Government disclaim all
  warranties, express or implied, including warranties of performance,
  merchantability or fitness for any particular purpose.
*/
/* Commit: $Id$ */

/*** Content Typography ***/

/* General declarations */

body {
    background-color: white;
    font: 12pt/1.75 arial,helvetica,clean,sans-serif
}

p, pre, blockquote, dl, menu, ol, ul {
    margin-top: 0.875em;
    margin-bottom: 0.875em;
    display: block;
}

blockquote.pullquote {
    position: relative;
    font-style: italic;
    font-size: 1.125em;
    line-height: 1.5;
    margin: 0.875em 1em;
}

img {
    max-width:100%;
    max-height:100%;
}

img, figure, .iconblock, a {
    -webkit-box-sizing: border-box;
    -moz-box-sizing: border-box;
    box-sizing: border-box;
}

/*  optional standard helpers */
.uppercase{text-transform: uppercase;letter-spacing:.06em;}
.caps{text-transform:capitalize;}
.small-caps{text-transform: lowercase; font-variant:small-caps;letter-spacing:.02em;}
.overline{text-decoration:overline;}
.roman{font-style:normal}
.greek{font-family:Georgia, Times,"Times New Roman", serif}

/* article */
article {
    /*font: 12pt/1.75 Georgia, "Times New Roman", Times, serif;*/ /* 16/28 */
    font: 13pt/1.75 "Times New Roman", serif;
    word-wrap:break-word;
}

a {
    color:#2f4a8b;
    text-decoration: none;
}

a:hover, article a:active {
    color:#985735
}

a:visited {
    color:#642a8f
}

a[disabled], a[disabled]:active, a[disabled]:visited, a[disabled]:hover {
    color: #ddd;
    background-color: #f8f8f8;
}

/* journal / publisher branding */
article .jrb-schm1 {
    margin:auto;
    max-width: 6in;
    text-align: center;
    line-height: 0;
}
article .jrb {
    background: hsl(204, 33%, 85%) url(../img/jrb.back.jpg);
    -webkit-background-size: cover;
    -moz-background-size: cover;
    -o-background-size: cover;
    background-size: cover;
    line-height: 16pt;
    padding: 2pt 6pt;
    margin: auto;
    max-width: 6in;
    font-family: sans-serif;
}

article .jrb.ms {
    background: hsl(204, 10%, 55%) url(../img/jrb.back.ms.jpg);
    -webkit-background-size: cover;
    -moz-background-size: cover;
    -o-background-size: cover;
    background-size: cover;
}

article .jrb .t a,
article .jrb .t {
    color: #464646;
}

article .jrb .t {
    text-align: center;
    font-size: 18pt;
    line-height: 1.5;
}

article .jrb .p {
    text-align: right;
    color: #A64;
    font-size: 10pt;
}

article .jrb.ms .ams {
    color: #A64;
    float: left;
    font-size: 10pt;
}


/* vip notices, next to the banner */
.vip-notice {
    -webkit-border-radius: 6pt;
    -moz-border-radius: 6pt;
    border-radius: 6pt;
    border: 1px solid  hsl(21, 60%, 80%);
    padding: 6pt;
    text-align: center;
    font-family: "Archivo Narrow", "Arial Narrow", "Trebuchet MS", ArialMT, Arial, sans-serif;
    background-color: hsl(48,100%,90%);
    margin: 0.875em 0;
    font-size: 0.9375em;
    line-height: 1.5;
}

.vip-notice .notice,
.vip-notice strong {
    text-transform: uppercase;
    display: block;
}

.vip-notice.retraction .notice {
    color: red;
}

.vip-notice p:first-child {
    margin-top: 0;
}

.vip-notice p:last-child {
    margin-bottom: 0;
}

/* headers and front matter */
article header,
article .fm-sec,
.ref-list-sec {
    font-size: 0.9375em;
    line-height: 1.8667;
}

article header,
article .fm-sec,
article h1,
article h2,
article h3,
article h4,
article h5,
article h6 {
    font-family: "Archivo Narrow", "Arial Narrow", "Trebuchet MS", ArialMT, Arial, sans-serif;
    margin-bottom: 0;
    font-weight: normal;
}

h1, h2, h3, h4, h5, h6 {
    -webkit-column-break-after: avoid;
    -moz-column-break-after: avoid;
    column-break-after: avoid;
    -webkit-column-break-inside:avoid;
    -moz-column-break-inside: avoid;
    column-break-inside: avoid;
}

article h1,
article h2 {font-size: 1.5em;    line-height: 1.1667; margin: 1.1667em 0 .5834em 0;} /*24/36 margin-top=28 bold black*/
article h2 {color: hsl(21, 45%, 50%)}
article h3 {font-size: 1.3125em; line-height: 1.3333; margin: 1.3333em 0 .6667em 0; color: hsl(21, 45%, 40%);} /*21/28 margin-top=28 normal copper*/
article h4 {font-size: 1.1250em; line-height: 1.5556; margin: 1.5556em 0 .7778em 0; color: hsl(21, 45%, 35%);} /*18/28 margin-top=28 normal copper*/
article h5,
article h6 {font-size: 1em;      line-height: 1.75;   margin: 1.7500em 0 .8750em 0;} /*16/28 margin-top=28 normal copper*/
article h5 {color: hsl(21, 45%, 30%)}
article h6 {color: hsl(21, 40%, 25%)} 


article strong {
    font-size: 0.925em;
}

article header h1,
article .fm-sec h1 {
    font-size: 1.7067em;
}

article header h6,
article header p,
article .fm-sec h6,
article .fm-sec p {
    margin: 1.0667em 0;
}

article header .contribs,
article .fm-sec .contribs {
    font-size: 1.2em;
    margin: .8889em 0;

}

article header strong,
article .fm-sec strong {
    font-size: 1em;
}

/* front matter panels */
.fm-panel, .fm-author, .fm-citation {
    margin: 1.0667em 0;
}

/* reference section */
.ref-list-sec,
.ref-list-sec > div {
    margin: 1.0667em 0;
}


/* inline headers */

article h2.inline,
article h3.inline,
article h4.inline,
article h5.inline,
article h6.inline {
    font-size: 1em;
}

article .inline + p {
    display: inline;
}

article .inline {
    display: inline;
    margin-right: 0.25em;
}

/* tables and figures */
table {
    table-layout:fixed;
    max-width: 100%;
    border-collapse: separate;
    border-spacing:0.5em;
}

table.rendered  td,
table.rendered  th {
    vertical-align: top;
    padding: .2em .4em; /* vert horiz */
}

/* we want to clip large tables in the main content view, but not in table view.
   check PMC-16055 before changing or removing next class. */
article[data-type=main] .large_tbl {
    overflow: hidden;
}

.iconblock, table, figure {
    font-size: 0.875em;
    line-height: 1.714;
    margin: 1.1429em 0;
}

.tblwrap-foot {
    font-size: 0.8em;
    line-height: 1.875;
    margin: 1.25em 0
}

.iconblock, figure {
    color: #888;
    display: table;
    width: 100%;
    padding: 6pt;
    border: #E0ECFF double 4pt;
    -webkit-border-radius: 6pt;
    -moz-border-radius: 6pt;
    border-radius: 6pt;
    -webkit-column-break-inside: avoid;
    -moz-column-break-inside: avoid;
    column-break-inside: avoid;
}

.iconblock .icnblk_img,
.iconblock > a, figure > a {
    min-width: 100px;
    text-align: center;
    display: table-cell;
    vertical-align: top;
}

.iconblock .icnblk_cntnt,
figure figcaption {
    display: table-cell;
    vertical-align: top;
    width: 100%;
}


.iconblock > a > img,
figure > a > img {
    max-width: 100px;
    max-height: 100px;
    margin: 0 6pt 6pt 0;
    width: auto;
    vertical-align: top;
}

.graphic_only img {
    max-width: 2in;
}


article[data-type=main] .fig .caption,
.fig .attrib {
    color: #888;
    font-size: 0.875em;
    line-height: 1.5;
}

.fig .attrib {
    text-align: right;
    margin: 1em 0 1em 2em;
}

/* boxed text */
.boxed-text-box {
    background: #eee;
    padding: 0 1em;
    -webkit-column-break-inside: avoid;
    -moz-column-break-inside: avoid;
    column-break-inside: avoid;
}

/* math */
div.disp-formula {
    display: table;
    table-layout: fixed;
    width: 100%;
    margin: 1em 0;
}

div.disp-formula .f,
div.disp-formula .l {
    display: table-cell;
    text-align: center;
}

div.disp-formula .f {
    width: 90%;
}

div.disp-formula .l {
    width: 10%;
    color: hsl(21, 100%, 50%);
    text-shadow: 0 0 1.5em #000;
    white-space: nowrap;
    vertical-align: middle;
}

img.equation,
div.disp-formula .f img.eq-image {
    vertical-align: middle;
}

/* MathJax adjustments */
.MathJax_SVG_Display { /* block math */
    margin:0 !important;
}

span.MathJax_SVG,
span.MathJax_SVG svg { /* inline math */
    max-width: 100% !important;
}

#MathJax_Zoom span.MathJax_SVG,
#MathJax_Zoom span.MathJax_SVG svg { /* inline math inside zoom panel */
    max-width: none !important;
}

#MathJax_MenuFrame {
  z-index: 1000 !important
}

/* custom underlining */

span.underline {
    border-bottom: 1px solid #777;
}

span.double-underline {
    border-bottom: 3px double #777;
}

span.bold-double-underline {
    border-bottom: 3px double black;
}

/* doi */

.doi {white-space:nowrap}

/* lists */
.lower-alpha{list-style-type:lower-alpha}
.upper-alpha{list-style-type:upper-alpha}
.lower-roman{list-style-type:lower-roman}
.upper-roman{list-style-type:upper-roman}
.circle{list-style-type:circle}
.square{list-style-type:square}
.simple-list{list-style-type:none}
.first-line-outdent{list-style-type:none}
.first-line-outdent li:first-letter{margin-left:-1.5em}

/* verse */
p.verse-group {
    font-style: italic;
    margin-left: 1.75em;
    color: #444;
}

/* tileshop related definitions */
.ts_canvas {
    display: inline-block;
    max-width: 100%;
}

.ts_canvas img {
    -moz-box-shadow: 0 0 3px #fff, 0 0 6px #333;
    -webkit-box-shadow: 0 0 3px #fff, 0 0 6px #333;
    box-shadow: 0 0 3px #fff, 0 0 6px #333;
}

.ts_bar {
    height:0;
    position: relative;
}

.ts_bar:after {
    content: url(../img/mglss24.png);
    position: absolute;
    height: 24px;
    width: 24px;
    right: -13px;
    top: -9px;
}

/* utility definitions */
.nowrap {white-space: nowrap}

/* unordered list */
ul li.a_label {
    position: relative;
    list-style-type: none;
}

ul li.a_label div.a_label {
    position: absolute;
    left: -2em;
    width: 1.85em;
    text-align: right;
}

/* suppdata */
.suppmat {
  border: #E4E4E4 double 4pt;
  border-radius: 4pt;
  padding: 6pt;
  margin: 1.1429em 0;
  -webkit-column-break-inside: avoid;
  -moz-column-break-inside: avoid;
  column-break-inside: avoid;
}
/* force alignment */
.align_center {
    text-align: center;
}

.align_right {
    text-align: right;
}

.left {
    float: left;
}

/* multulingual abstracts, titles */


article h1[lang],
article div[lang],
article span[lang]

{
    display: none;
}

.slang-all h1[lang],
.slang-ar h1[lang="ar"],
.slang-bg h1[lang="bg"],
.slang-cs h1[lang="cs"],
.slang-da h1[lang="da"],
.slang-de h1[lang="de"],
.slang-en h1[lang="en"],
.slang-es h1[lang="es"],
.slang-fa h1[lang="fa"],
.slang-fi h1[lang="fi"],
.slang-fr h1[lang="fr"],
.slang-ga h1[lang="ga"],
.slang-hu h1[lang="hu"],
.slang-is h1[lang="is"],
.slang-it h1[lang="it"],
.slang-ja h1[lang="ja"],
.slang-ko h1[lang="ko"],
.slang-my h1[lang="my"],
.slang-ms h1[lang="ms"],
.slang-nl h1[lang="nl"],
.slang-no h1[lang="no"],
.slang-pl h1[lang="pl"],
.slang-pt h1[lang="pt"],
.slang-ro h1[lang="ro"],
.slang-ru h1[lang="ru"],
.slang-sk h1[lang="sk"],
.slang-sl h1[lang="sl"],
.slang-sv h1[lang="sv"],
.slang-tr h1[lang="tr"],
.slang-uk h1[lang="uk"],
.slang-zh h1[lang="zh"],
.slang-all div[lang],
.slang-ar div[lang="ar"],
.slang-bg div[lang="bg"],
.slang-cs div[lang="cs"],
.slang-da div[lang="da"],
.slang-de div[lang="de"],
.slang-en div[lang="en"],
.slang-es div[lang="es"],
.slang-fa div[lang="fa"],
.slang-fi div[lang="fi"],
.slang-fr div[lang="fr"],
.slang-ga div[lang="ga"],
.slang-hu div[lang="hu"],
.slang-is div[lang="is"],
.slang-it div[lang="it"],
.slang-ja div[lang="ja"],
.slang-ko div[lang="ko"],
.slang-my div[lang="my"],
.slang-ms div[lang="ms"],
.slang-nl div[lang="nl"],
.slang-no div[lang="no"],
.slang-pl div[lang="pl"],
.slang-pt div[lang="pt"],
.slang-ro div[lang="ro"],
.slang-ru div[lang="ru"],
.slang-sk div[lang="sk"],
.slang-sl div[lang="sl"],
.slang-sv div[lang="sv"],
.slang-tr div[lang="tr"],
.slang-uk div[lang="uk"],
.slang-zh div[lang="zh"]
{
    display: block !important;
}

.slang-all span[lang],
.slang-ar span[lang="ar"],
.slang-bg span[lang="bg"],
.slang-cs span[lang="cs"],
.slang-da span[lang="da"],
.slang-de span[lang="de"],
.slang-en span[lang="en"],
.slang-es span[lang="es"],
.slang-fa span[lang="fa"],
.slang-fi span[lang="fi"],
.slang-fr span[lang="fr"],
.slang-ga span[lang="ga"],
.slang-hu span[lang="hu"],
.slang-is span[lang="is"],
.slang-it span[lang="it"],
.slang-ja span[lang="ja"],
.slang-ko span[lang="ko"],
.slang-my span[lang="my"],
.slang-ms span[lang="ms"],
.slang-nl span[lang="nl"],
.slang-no span[lang="no"],
.slang-pl span[lang="pl"],
.slang-pt span[lang="pt"],
.slang-ro span[lang="ro"],
.slang-ru span[lang="ru"],
.slang-sk span[lang="sk"],
.slang-sl span[lang="sl"],
.slang-sv span[lang="sv"],
.slang-tr span[lang="tr"],
.slang-uk span[lang="uk"],
.slang-zh span[lang="zh"]
{
    display: inline !important;
}

h1[lang="ar"], 
div[lang="ar"],
span[lang="ar"]
{
    text-align: right;
    direction: rtl;
}

a.lang-sw.selected,
a.lang-sw.selected:visited
{
    color: #666;
    text-decoration: none !important;
}

.mul-switcher {
    text-align: right;
    padding-left: 20%;
}

/* end of multulingual abstracts, titles */

a.oemail {
    unicode-bidi: bidi-override;
    direction: rtl;
    white-space: nowrap;
}

/* class for named-content see PMC-27848*/
.dna-sequence {
    word-break:break-all;
    font-style: normal;
}   

/* PMC-27757 copyright and reuse links */
.fm-reuse {
    margin-left: 3em;
}

.fm-copyright-license {
    margin: 0;
    margin-bottom: 1.75em;
}

/* print media definitions */
@media print {
    body, article {
        font-size: 8pt;
    }

    article .jrb,
    article .jrb-schm1,
    .fm-aai {
        display: none;
    }
}