File Comparison Report

121 <xs:element minOccurs="0" name="DeletedSCVList">

−

121                <xs:element maxOccurs="1" minOccurs="0" name="StrengthMappingList">
122                    <xs:complexType>
123                        <xs:sequence>
124                            <xs:element maxOccurs="unbounded" name="StrengthMapping">
125                                <xs:complexType>
126                                    <xs:sequence>
127                                        <xs:element name="Source" minOccurs="0" maxOccurs="1">
128                                            <xs:complexType>
129                                                <xs:sequence>
130                                                    <xs:element name="Name" type="xs:string" minOccurs="0" maxOccurs="1"/>
131                                                    <xs:element name="OrgID" type="xs:positiveInteger" minOccurs="0" maxOccurs="1"/>
132                                                </xs:sequence>
133                                            </xs:complexType>
134                                        </xs:element>
135                                        <xs:element name="AccessionList" minOccurs="1" maxOccurs="1">
136                                            <xs:complexType>
137                                                <xs:sequence>
138                                                    <xs:element name="Accession" type="xs:string" minOccurs="1" maxOccurs="unbounded"/>
139                                                </xs:sequence>
140                                            </xs:complexType>
141                                        </xs:element>
142                                        <xs:element name="FunctionalEvidenceStrength" minOccurs="1" maxOccurs="1">
143                                            <xs:complexType>
144                                                <xs:sequence>
145                                                    <xs:element name="Strength" type="xs:string" minOccurs="1" maxOccurs="1"/>
146                                                    <xs:element name="Comment" type="xs:string" minOccurs="0" maxOccurs="1"/>
147                                                    <xs:element name="Guideline" type="typeCitation" minOccurs="0" maxOccurs="1"/>
148                                                </xs:sequence>
149                                            </xs:complexType>
150                                        </xs:element>
151                                    </xs:sequence>
152                                </xs:complexType>
153                            </xs:element>
154                        </xs:sequence>
155                    </xs:complexType>
156                </xs:element>
157                <xs:element minOccurs="0" name="DeletedSCVList">

280 <xs:enumeration value="variant to named protein"/>

−

316 <xs:enumeration value="variant to named protein"/>
317 <xs:enumeration value="no classification"/>

321 <xs:simpleType name="typeOrigin">

−

358    <xs:simpleType name="typeAggregateNoClassificationReviewStatusValue">
359        <xs:restriction base="xs:string">
360            <xs:enumeration value="no classification provided"/>
361        </xs:restriction>
362    </xs:simpleType>
363    <xs:simpleType name="typeOrigin">

1470    <xs:complexType name="typeAggregateClassificationSet">
1471        <xs:annotation>
1472            <xs:documentation>Used to bundle different types of Classifications (germline, oncogenic, somatic clinical impact)
1473                ; Supports summary as well as submission
1474                details</xs:documentation>
1475        </xs:annotation>
1476        <xs:sequence>

∗

1512    <xs:complexType name="typeSingleNoClassification">
1513        <xs:sequence>
1514            <xs:element maxOccurs="1" minOccurs="1" name="ReviewStatus"
1515                type="typeAggregateNoClassificationReviewStatusValue">
1516                <xs:annotation>
1517                    <xs:documentation>The aggregate review status based on all no-classification submissions
1518                        for this record.</xs:documentation>
1519                </xs:annotation>
1520            </xs:element>
1521            <xs:element maxOccurs="1" minOccurs="0" name="Description" type="xs:string">
1522                <xs:annotation>
1523                    <xs:documentation>We are not providing an enumeration for the values we report
1524                        for no-classification classification within the xsd. Details are in https://github.com/ncbi/clinvar/ClassificationOnClinVar.md.</xs:documentation>
1525                </xs:annotation>
1526            </xs:element>
1527            <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="typeXref"/>
1528            <xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="typeCitation"/>
1529            <xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="typeComment"/>
1530        </xs:sequence>
1531    </xs:complexType>
1532    <xs:complexType name="typeAggregateClassificationSet">
1533        <xs:annotation>
1534            <xs:documentation>Used to bundle different types of Classifications (germline, oncogenic, somatic clinical impact, no-classification)
1535                ; Supports summary as well as submission
1536                details</xs:documentation>
1537        </xs:annotation>
1538        <xs:sequence>

1482 type="typeAggregatedOncogenicityClassification"/>

−

1544                type="typeAggregatedOncogenicityClassification"/>
1545            <xs:element maxOccurs="1" minOccurs="0" name="NoClassification"
1546                type="typeAggregatedNoClassification"/>

1557 <xs:complexType name="typeDescriptionHistory">

−

1621    <xs:complexType name="typeAggregatedNoClassification">
1622        <xs:complexContent>
1623            <xs:extension base="typeSingleNoClassification">
1624                <xs:sequence>
1625                    <xs:element maxOccurs="unbounded" minOccurs="0" name="DescriptionHistory"
1626                        type="typeDescriptionHistory"/>
1627                    <xs:element maxOccurs="1" minOccurs="0" name="ConditionList">
1628                        <xs:complexType>
1629                            <xs:sequence>
1630                                <xs:element maxOccurs="unbounded" minOccurs="1" name="TraitSet"
1631                                    type="ClinAsserTraitSetType"/>
1632                            </xs:sequence>
1633                        </xs:complexType>
1634                    </xs:element>
1635                </xs:sequence>
1636                <xs:attribute name="DateCreated" type="xs:date"/>
1637                <xs:attribute name="MostRecentSubmission" type="xs:date"/>
1638                <xs:attribute name="NumberOfSubmitters" type="xs:nonNegativeInteger" use="required"/>
1639                <xs:attribute name="NumberOfSubmissions" type="xs:nonNegativeInteger" use="required"/>
1640                <xs:attribute name="Type" type="xs:string" use="optional"/>
1641            </xs:extension>
1642        </xs:complexContent>
1643    </xs:complexType>
1644    <xs:complexType name="typeDescriptionHistory">

1659 </xs:element>

−

1746                        </xs:element>
1747                        <xs:element maxOccurs="1" minOccurs="0" name="NoClassification">
1748                            <xs:complexType>
1749                                <xs:sequence>
1750                                    <xs:element maxOccurs="1" name="ReviewStatus"
1751                                        type="typeAggregateNoClassificationReviewStatusValue">
1752                                        <xs:annotation>
1753                                            <xs:documentation>The aggregate review status based on
1754                                                all no-classification submissions for this
1755                                                record.</xs:documentation>
1756                                        </xs:annotation>
1757                                    </xs:element>
1758                                    <xs:element name="Description">
1759                                        <xs:complexType>
1760                                            <xs:simpleContent>
1761                                                <xs:extension base="xs:string">
1762                                                  <xs:attribute name="SubmissionCount"
1763                                                  type="xs:nonNegativeInteger"/>
1764                                                </xs:extension>
1765                                            </xs:simpleContent>
1766                                        </xs:complexType>
1767                                    </xs:element>
1768                                </xs:sequence>
1769                            </xs:complexType>
1770                        </xs:element>

2048 type="xs:string"/>

−

2159                    type="xs:string"/>
2160                <xs:element maxOccurs="1" minOccurs="0" name="NoClassification"
2161                    type="xs:string"/>

2166

−

2279            <xs:element name="AssayType" type="xs:string" minOccurs="0" maxOccurs="1"/>
2280            <xs:element name="MolecularPhenotypeMeasured" type="xs:string" minOccurs="0" maxOccurs="1"/>
2281            <xs:element name="NumberOfReplicates" type="xs:positiveInteger" minOccurs="0" maxOccurs="1"/>
2282            <xs:element name="NumberOfControls" type="xs:positiveInteger" minOccurs="0" maxOccurs="1"/>
2283            <xs:element name="ScoringRanges" type="ScoringRangesType" minOccurs="0" maxOccurs="1"/>

2168 <xs:complexType name="ObservationSet">

−

2286    <xs:complexType name="ScoringRangesType">
2287        <xs:sequence>
2288            <xs:element name="Range" minOccurs="1" maxOccurs="unbounded">
2289                <xs:complexType>
2290                    <xs:sequence>
2291                        <xs:element name="Label" type="xs:string" minOccurs="1" maxOccurs="1"/>
2292                        <xs:choice minOccurs="1" maxOccurs="2">
2293                            <xs:element name="UpperLimit" type="xs:decimal"/>
2294                            <xs:element name="LowerLimit" type="xs:decimal"/>
2295                        </xs:choice>
2296                    </xs:sequence>
2297                </xs:complexType>
2298            </xs:element>
2299        </xs:sequence>
2300    </xs:complexType>
2301    <xs:complexType name="ObservationSet">

2203            <xs:element maxOccurs="unbounded" minOccurs="1" name="ObservedData">
2204                <xs:annotation>
2205                    <xs:documentation>This is an AttributeSet, there will be 1 attribute supported
2206                        by                   optional citations, xrefs and comment. There must be at
2207                        least one ObservedData                   Set, but can be any number. For
2208                        each ObservedData set the Attribute will be either                   decimal
2209                        or string depending on type. The value will be stored here, but decimals
2210                        will be entered to the database as a string. </xs:documentation>
2211                </xs:annotation>
2212                <xs:complexType>
2213                    <xs:sequence>
2214                        <xs:element name="Attribute">
2215                            <xs:complexType>
2216                                <xs:simpleContent>
2217                                    <xs:extension base="typeAttribute">
2218                                        <xs:attribute name="Type" use="required">
2219                                            <xs:simpleType>
2220                                                <xs:restriction base="xs:string">
2221                                                  <xs:enumeration value="Description"/>
2222                                                  <xs:enumeration value="VariantAlleles"/>
2223                                                  <xs:enumeration value="SubjectsWithVariant"/>
2224                                                  <xs:enumeration
2225                                                  value="SubjectsWithDifferentCausativeVariant"/>
2226                                                  <xs:enumeration value="VariantChromosomes"/>
2227                                                  
2228                                                  <xs:enumeration value="IndependentObservations"/>
2229                                                  <xs:enumeration value="SingleHeterozygote"/>
2230                                                  <xs:enumeration value="CompoundHeterozygote"/>
2231                                                  <xs:enumeration value="Homozygote"/>
2232                                                  <xs:enumeration value="Hemizygote"/>
2233                                                  <xs:enumeration value="NumberMosaic"/>
2234                                                  <xs:enumeration value="ObservedUnspecified"/>
2235                                                  <xs:enumeration value="AlleleFrequency"/>
2236                                                  <xs:enumeration value="SecondaryFinding"/>
2237                                                  
2238                                                  <xs:enumeration value="GenotypeAndMOIConsistent"/>
2239                                                  <xs:enumeration
2240                                                  value="UnaffectedFamilyMemberWithCausativeVariant"/>
2241                                                  <xs:enumeration
2242                                                  value="HetParentTransmitNormalAllele"/>
2243                                                  <xs:enumeration value="CosegregatingFamilies"/>
2244                                                  <xs:enumeration value="InformativeMeioses"/>
2245                                                  <xs:enumeration value="SampleLocalID"/>
2246                                                  <xs:enumeration value="SampleVariantID"/>
2247                                                  <xs:enumeration value="FamilyHistory"/>
2248                                                  <xs:enumeration value="NumFamiliesWithVariant"/>
2249                                                  <xs:enumeration
2250                                                  value="NumFamiliesWithSegregationObserved"/>
2251                                                  <xs:enumeration value="SegregationObserved"/>
2252                                                </xs:restriction>
2253                                            </xs:simpleType>
2254                                        </xs:attribute>
2255                                    </xs:extension>
2256                                </xs:simpleContent>
2257                            </xs:complexType>
2258                        </xs:element>
2259                        <xs:element maxOccurs="1" minOccurs="0" name="Severity" type="typeSeverity"/>
2260                        <xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
2261                            type="typeCitation"/>
2262                        <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="typeXref"/>
2263                        <xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
2264                            type="typeComment"/>
2265                    </xs:sequence>
2266                </xs:complexType>
2267            </xs:element>

∗

2336            <xs:choice minOccurs="1" maxOccurs="unbounded">
2337                <xs:element name="ObservedData" type="ObservedDataType" minOccurs="0"
2338                    maxOccurs="unbounded"> </xs:element>
2339                <xs:element name="FunctionalData" type="FunctionalDataType" minOccurs="0"
2340                    maxOccurs="1"> </xs:element>
2341            </xs:choice>

2274 </xs:sequence>

−

2348 </xs:sequence>
2349 <xs:attribute name="Type" type="xs:string" use="optional"/>

2276 <xs:complexType name="ClinAsserTraitSetType">

−

2351    <xs:complexType name="ObservedDataType">
2352        <xs:annotation>
2353            <xs:documentation>This is an AttributeSet, there will be 1 attribute supported
2354                by                   optional citations, xrefs and comment. There must be at
2355                least one ObservedData                   Set, but can be any number. For
2356                each ObservedData set the Attribute will be either                   decimal
2357                or string depending on type. The value will be stored here, but decimals
2358                will be entered to the database as a string. </xs:documentation>
2359        </xs:annotation>
2360        <xs:sequence>
2361            <xs:element name="Attribute">
2362                <xs:complexType>
2363                    <xs:simpleContent>
2364                        <xs:extension base="typeAttribute">
2365                            <xs:attribute name="Type" use="required">
2366                                <xs:simpleType>
2367                                    <xs:restriction base="xs:string">
2368                                        <xs:enumeration value="Description"/>
2369                                        <xs:enumeration value="VariantAlleles"/>
2370                                        <xs:enumeration value="SubjectsWithVariant"/>
2371                                        <xs:enumeration
2372                                        value="SubjectsWithDifferentCausativeVariant"/>
2373                                        <xs:enumeration value="VariantChromosomes"/>
2374                                        
2375                                        <xs:enumeration value="IndependentObservations"/>
2376                                        <xs:enumeration value="SingleHeterozygote"/>
2377                                        <xs:enumeration value="CompoundHeterozygote"/>
2378                                        <xs:enumeration value="Homozygote"/>
2379                                        <xs:enumeration value="Hemizygote"/>
2380                                        <xs:enumeration value="NumberMosaic"/>
2381                                        <xs:enumeration value="ObservedUnspecified"/>
2382                                        <xs:enumeration value="AlleleFrequency"/>
2383                                        <xs:enumeration value="SecondaryFinding"/>
2384                                        
2385                                        <xs:enumeration value="GenotypeAndMOIConsistent"/>
2386                                        <xs:enumeration
2387                                        value="UnaffectedFamilyMemberWithCausativeVariant"/>
2388                                        <xs:enumeration
2389                                        value="HetParentTransmitNormalAllele"/>
2390                                        <xs:enumeration value="CosegregatingFamilies"/>
2391                                        <xs:enumeration value="InformativeMeioses"/>
2392                                        <xs:enumeration value="SampleLocalID"/>
2393                                        <xs:enumeration value="SampleVariantID"/>
2394                                        <xs:enumeration value="FamilyHistory"/>
2395                                        <xs:enumeration value="NumFamiliesWithVariant"/>
2396                                        <xs:enumeration
2397                                        value="NumFamiliesWithSegregationObserved"/>
2398                                        <xs:enumeration value="SegregationObserved"/>
2399                                    </xs:restriction>
2400                                </xs:simpleType>
2401                            </xs:attribute>
2402                        </xs:extension>
2403                    </xs:simpleContent>
2404                </xs:complexType>
2405            </xs:element>
2406            <xs:element maxOccurs="1" minOccurs="0" name="Severity" type="typeSeverity"/>
2407            <xs:element maxOccurs="unbounded" minOccurs="0" name="Citation"
2408                type="typeCitation"/>
2409            <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="typeXref"/>
2410            <xs:element maxOccurs="unbounded" minOccurs="0" name="Comment"
2411                type="typeComment"/>
2412        </xs:sequence>
2413    </xs:complexType>
2414    <xs:complexType name="FunctionalDataType">
2415        <xs:sequence>
2416            <xs:element name="FunctionalEffect" minOccurs="1" maxOccurs="1" type="xs:string"> </xs:element>
2417            <xs:element name="FunctionalConsequence" minOccurs="1" maxOccurs="1" type="xs:string"> </xs:element>
2418            <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="typeXref"></xs:element>
2419            <xs:element name="FunctionalConsequenceComment" minOccurs="0" maxOccurs="1" type="xs:string"> </xs:element>
2420            <xs:element name="Result" minOccurs="1" maxOccurs="1" type="xs:string"> </xs:element>
2421        </xs:sequence>
2422    </xs:complexType>
2423    <xs:complexType name="ClinAsserTraitSetType">